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Latest Heart News THURSDAY, June 9, 2022 (American Heart Association News) Elizabeth Gilberg blog recently cheap seroquel canada picked up a few new skills. At 50, she's learned to knit and is relearning how to quilt. She took cheap seroquel canada lessons in cross-country skiing and tried her hand at beekeeping. Bike riding didn't go so well, but she's game to keep trying.

Like many women whose children have grown, Gilberg, a mother of four, now has more time for herself. The difference is, she wasn't sure she'd live this cheap seroquel canada long. "I'm so grateful that I'm still here to have all of this joy every day," she said. "I never thought I'd see my kids graduate high school." Two weeks after giving birth to Grace, her second daughter and fourth child, Gilberg woke up with a terrible headache.

That morning in early November, she cheap seroquel canada dropped off her other three children, ages 3 to 7, at their schools. She called her then-husband, who had just set up practice as a family doctor in their new hometown of Columbia Falls, Montana, to tell him about the headache. That's all she remembers. After a cheap seroquel canada few minutes of not being able to reach Gilberg, her husband went home to check on her.

He found the car and house doors open. Gilberg, then 32, was sitting on the floor holding Grace in her right arm. Her left arm cheap seroquel canada hung loose. She was speaking slowly, slurring her words.

He recognized the symptoms of stroke and called 911. Doctors found that Gilberg had experienced two cheap seroquel canada strokes, one on each side of her brain. Blood flowing out of her brain had backed up, causing clots in the main vein to her brain. The condition is called dural sinus thrombosis.

Usually, the cause is related to an cheap seroquel canada increased tendency to clot, which can occur with pregnancy. She was flown to a hospital in Portland, Oregon, for a then-experimental procedure. Clot-busting medication was delivered directly to the clots via a scope through her groin. It worked cheap seroquel canada.

Still, the stroke caused damage. Gilberg initially was paralyzed on her left side and had vision problems. For two months, she cheap seroquel canada also was delusional and paranoid. She didn't remember giving birth.

She stayed in the hospital for two months, relearning how to walk, talk, eat and read. Her parents and younger sister took turns staying with her, while her in-laws helped take care of the four cheap seroquel canada children. Townspeople cooked and delivered meals for several months. Gilberg went home in time for Christmas but still faced several more months of outpatient rehab.

Finally, after more than six months, she was able to return cheap seroquel canada to driving and being a mother and wife. However, things had changed. Her executive functioning skills – such as planning, working memory, time management and flexible thinking – had deteriorated. Folks in Columbia Falls gave her the help she cheap seroquel canada needed.

If she couldn't find her car in a parking lot, store employees would help. If there was an early-release day at school, someone in the office would call ahead to remind her. In the case of dental appointments, the receptionist would always call 20 minutes ahead of any appointment so it wouldn't slip cheap seroquel canada through the cracks. "Just yesterday, I got a reminder about a form I was supposed to fill out to help with my daughter's senior party," she said.

"I'm down to volunteer for everything, but I need help figuring out the logistics of it all." Gilberg, who remarried in 2016, jokes that it's fortunate her husband, Michael, is an accountant. "I really cheap seroquel canada can't add or subtract," she said. For a recent trip to Germany with her elder daughter, Gilberg – who majored in German in college and speaks the language – relied on German friends to plan the trip. "There is no shame in saying, 'I can't do this alone,'" Gilberg said.

"I think that's one of the things cheap seroquel canada that's allowed me to come as far as I have. Also, I have hugely simplified what I can deal with and handle at a certain time." She also reaches out to others who need help, especially stroke survivors. "If I could have seen someone my age who got better, that would have helped my recovery," she said. "I've been to cheap seroquel canada where I can't talk and I can't feed myself, so to see where I am now, maybe that can give someone hope." Victoria Rutherford, Gilberg's younger sister, left her teaching job for half a year to help after the stroke.

"I didn't think she would be where she is now," Rutherford said. "She just continues to improve. She's also a much deeper human and relates cheap seroquel canada to people who struggle on a much deeper level." SLIDESHOW What Happens After a Stroke?. Signs, Symptoms, Types See Slideshow After nearly 20 years, Gilberg will soon leave Columbia Falls.

As difficult as it is for her to leave her friends and supportive community, the move is best for her health. Several years ago, Gilberg was diagnosed with lupus, a disease of the immune system that cheap seroquel canada can be associated with a high chance of blood clots. Warmer weather in Utah will lessen flare-ups. "It's hard to imagine a better place to have lived in through all this," she said.

"But I cheap seroquel canada have a wonderful partner and some brain space to continue to expand what I've got going on here. I feel so much excitement for my life and the future." American Heart Association News covers heart and brain health. Not all views expressed in this story reflect the official position of the American Heart Association. Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved cheap seroquel canada.

If you have questions or comments about this story, please email [email protected]. By Diane Daniel, American Heart Association News By American Heart Association News HealthDay Reporter Copyright © 2021 HealthDay. All rights cheap seroquel canada reserved. From Healthy Resources Featured Centers Health Solutions From Our SponsorsLatest Sleep News By Cara Murez HealthDay ReporterFRIDAY, June 10, 2022 You might think that having the whole bed to yourself would leave you feeling more refreshed in the morning than sleeping with someone who might toss, turn or snore.

Yet, a new study suggests that adults who share their beds with a partner have less severe insomnia, less fatigue and more sleep time. They also report being more satisfied with their lives and relationships, as well as having lower levels of cheap seroquel canada stress, depression and anxiety. "Even though you're sleeping next to someone who may snore and roll around, it did something that was just beneficial," said Michael Grandner, director of the Sleep and Health Research Program at the University of Arizona in Tucson, and senior author of the study. "What's interesting, it's not just that someone was there because when we asked the question about a child, the answers were very different," he added.

Study participants who slept with their child most nights reported more insomnia, more stress and worse mental well-being the day after cheap seroquel canada. "Is it because the reason the child's in the bed is because things are stressful?. Is it because children move around more during the night or are more likely to kick you?. Who knows? cheap seroquel canada.

" Grandner said. For the study, researchers used data from 1,007 working-age adults in Pennsylvania. The investigators found that people who slept with an adult partner fell asleep faster, stayed asleep longer and had less risk of cheap seroquel canada sleep apnea. Those who slept in the same bed as their child had higher odds for sleep apnea, more severe insomnia and less control over their sleep.

The findings are contrary to those from a lab setting that found people sleeping together had more shallow slumber and that a partner's movements tended to cause an arousal in the brain. "But when cheap seroquel canada you asked the people, they felt it was more positive," Grandner said. "And, so, this backs that up, that it's greater than the sum of its parts." Reasons for the new findings are speculative, but Grandner suggested that safety or socialization may be at their root. Throughout most of history, for example, humans tended to sleep in groups around the fire.

It may cheap seroquel canada be that on some level, people simply feel safer when another adult is in the bed. "There might be some evolutionary advantage that the humans have benefited from for most of our existence, but we don't really take advantage of any more because we're not all camping around the fire, seeing if a predator's going to wander into our camp, but maybe that machinery is still there and there's a drive towards not being alone when we're vulnerable and asleep," Gardner said. "I mean, is this proven?. No, but it's an idea." It could also be that people who are more depressed and anxious tend to sleep alone because of those challenges, he added cheap seroquel canada.

This could also vary by the person. If someone's partner causes a person to feel stress, they may feel more vulnerable in bed. "That's hard cheap seroquel canada to disentangle in a study like this, but at least what this study does, it shows that there's a connection, we can start making guesses as to what direction it goes in, and then we can start exploring them," Grandner said. The findings were recently published online in the journal Sleep and were presented Sunday at a meeting of the Associated Professional Sleep Societies, held in Charlotte, N.C.

Dr. Rafael Pelayo, a clinical cheap seroquel canada professor in sleep medicine at Stanford University in California, said the findings were consistent with his own observations. Pelayo, who was not involved in the study, also noted the history of sleeping in groups as a way to stay safe from predators. No one actually sleeps all through the night, he said, noting that people tend to wake at 90-minute intervals, very briefly, throughout the night.

Sleeping is a learned behavior, Pelayo said, which is why couples tend to cheap seroquel canada choose a side of the bed and not change that. One person tends to sleep more lightly and one more deeply. Being compatible in sleep, not just while awake, is important, he said. SLIDESHOW cheap seroquel canada Sleep Disorders.

Foods That Help Sleep or Keep You Awake See Slideshow Sleeping is an intimate experience because it requires spending hours together with your guard down, Pelayo said. "Over time, as you build that trust, then you'll sleep better," he said. "And you have many patients who tell you, and people in general, that cheap seroquel canada they don't sleep as well when their partner is away." Grandner said future research could investigate whether people sleep better or worse if they share a room but not a bed, as in a new trend that has people sleeping in two twins instead of together on one king-sized mattress where they would be more affected by someone else's movement. "The next steps are to just understand how do we use this information to actually make change and recommend changes for people?.

" he said. More information The Sleep Foundation has tips for better sleep. SOURCES. Michael Grandner, PhD, director, sleep and health research, University of Arizona College of Medicine, Tucson.

Rafael Pelayo, MD, clinical professor, psychiatry and behavioral sciences -- sleep medicine, Stanford University, Stanford, Calif., and author, "How to Sleep. The New Science-Based Solutions for Sleeping Through the Night". Sleep, May 25, 2022, online. Presentation, Associated Professional Sleep Societies, Charlotte, N.C., June 5, 2022 Copyright © 2021 HealthDay.

All rights reserved. From Sleep Resources Featured Centers Health Solutions From Our Sponsors.

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(1) The http://bobmackin.ca/?p=1002 necessity and utility of the proposed information collection for the proper generic seroquel online for sale performance of the agency's functions. (2) the accuracy of the estimated burden. (3) ways to enhance the quality, utility, and clarity of the information to be collected. And (4) generic seroquel online for sale the use of automated collection techniques or other forms of information technology to minimize the information collection burden.

Comments on the ICR must be received on or before June 21, 2022. Written comments and recommendations for the proposed information collection should be sent within 30 days of publication of this notice. To be assured consideration, comments and recommendations must generic seroquel online for sale be submitted www.reginfo.gov/​public/​do/​PRAMain. Find this particular information collection by selecting “Currently under 30-day Review—Open for Public Comments” or by using the search function.

Start Further Info Sherrette Funn, Sherrette.Funn@hhs.gov or (202) 795-7714. When submitting generic seroquel online for sale comments or requesting information, please include the document identifier 0990-0475-30D and project title for reference. End Further Info End Preamble Start Supplemental Information Interested persons are invited to send comments regarding this burden estimate or any other aspect of this collection of information, including any of the following subjects. (1) The necessity and utility of the proposed information collection for the proper performance of the agency's functions.

(2) the generic seroquel online for sale accuracy of the estimated burden. (3) ways to enhance the quality, utility, and clarity of the information to be collected. And (4) the use of automated collection techniques or other forms of information technology to minimize the information collection burden. Title of the Collection generic seroquel online for sale.

ASPA antidepressant drugs Public Education Campaign Evaluation Surveys. Type of Collection. Revision. OMB No.

0990-0475—Office of the Assistant Secretary for Public Affairs (ASPA) within Office of the Secretary. Abstract. The Office of the Assistant http://ninagilgfotografie.de/2018/12/10/the-most-wonderful-time/ Secretary for Public Affairs (ASPA), U.S. Department of Health and Human Services (HHS) is requesting a revision on a currently approved collection including two components.

1. antidepressant drugs Attitudes and Beliefs Survey (CABS), and 2. Monthly Outcome Survey (MOS). This revision supports continuation of the approved data collection by adding burden to support the program through the expiration of the package 0990-0475 on February 29, 2024.

Throughout execution of ASPA's COIVD-19 Public Education Campaign, this information will primarily be used to determine whether the campaign is having the intended impact on target audiences' knowledge, attitudes, and beliefs as they relate to antidepressant drugs, antidepressant drugs vaccination, boosting, and uptake of vaccination among eligible children, as well as adherence to preventative behaviors. It will also keep key stakeholders informed of the Campaign's progress. Ultimately, the data will inform a thorough evaluation of the efficacy of the campaign and its impact on treatment and booster uptake. antidepressant drugs Attitudes and Beliefs Survey (CABS) The CABS is a longitudinal survey that fields tri-annually to 4,000 U.S.

Adults through the duration of 0990-0475 via NORC at the University of Chicago's AmeriSpeak Panel. The survey is fielded online, and each fielding period lasts between 3 and 6 weeks. Those that respond to each wave of the survey are recontacted in each subsequent wave, facilitating a comparison of antidepressant drugs behavior change over time for a representative sample and evaluation of U.S. Adults.

Panel members selected to participate in the study received one pre-invitation postcard in the mail, one email invitation, and three email reminders to complete the survey in each wave. There are two CABS supplements to increase robustness of the evaluation, one to obtain enough parent respondents of eligible-to-vaccinate children and another to obtain respondents' media consumption habits. Monthly Outcome Survey (MOS) The MOS is a cross-sectional survey fielded monthly to 5,000 U.S. Adults over two years (24 waves) via the Ipsos KnowledgePanel 5K Omnibus Survey.

The is fielded online, and each fielding period lasts between 7 and 10 days. Estimated Annualized Burden TableType of respondentForm nameNumber of respondentsNumber responses per respondentAverage burden per response (in hours)Total burden hoursMOSMOS Survey Questionnaire120,000115/6030,000CABSCABS Survey Questionnaire3,800635/6013,300 Parent Supplement2,565135/601,497 Media Diet Supplement4,50017.5/60563Total45,360 Start Signature Sherrette A. Funn, Paperwork Reduction Act Reports Clearance Officer, Office of the Secretary. End Signature End Supplemental Information.

Start Preamble Office cheap seroquel canada of the Secretary, HHS. Notice. Interested persons are invited to send comments regarding this burden estimate or any other aspect of this collection of information, including any of the following subjects. (1) The necessity and cheap seroquel canada utility of the proposed information collection for the proper performance of the agency's functions.

(2) the accuracy of the estimated burden. (3) ways to enhance the quality, utility, and clarity of the information to be collected. And (4) the use of automated collection techniques or other forms of information technology to minimize cheap seroquel canada the information collection burden. Comments on the ICR must be received on or before June 21, 2022.

Written comments and recommendations for the proposed information collection should be sent within 30 days of publication of this notice. To be assured consideration, comments and cheap seroquel canada recommendations must be submitted www.reginfo.gov/​public/​do/​PRAMain. Find this particular information collection by selecting “Currently under 30-day Review—Open for Public Comments” or by using the search function. Start Further Info Sherrette Funn, Sherrette.Funn@hhs.gov or (202) 795-7714.

When submitting cheap seroquel canada comments or requesting information, please include the document identifier 0990-0475-30D and project title for reference. End Further Info End Preamble Start Supplemental Information Interested persons are invited to send comments regarding this burden estimate or any other aspect of this collection of information, including any of the following subjects. (1) The necessity and utility of the proposed information collection for the proper performance of the agency's functions. (2) the accuracy of cheap seroquel canada the estimated burden.

(3) ways to enhance the quality, utility, and clarity of the information to be collected. And (4) the use of automated collection techniques or other forms of information technology to minimize the information collection burden. Title of the cheap seroquel canada Collection. ASPA antidepressant drugs Public Education Campaign Evaluation Surveys.

Type of Collection. Revision. OMB cheap seroquel canada No. 0990-0475—Office of the Assistant Secretary for Public Affairs (ASPA) within Office of the Secretary.

Abstract. The Office of the Assistant Secretary for Public Affairs (ASPA), U.S cheap seroquel canada. Department of Health and Human Services (HHS) is requesting a revision on a currently approved collection including two components. 1.

antidepressant drugs Attitudes cheap seroquel canada and Beliefs Survey (CABS), and 2. Monthly Outcome Survey (MOS). This revision supports continuation of the approved data collection by adding burden to support the program through the expiration of the package 0990-0475 on February 29, 2024. Throughout execution of ASPA's COIVD-19 Public Education Campaign, this information will primarily be used to determine whether the campaign is having the intended impact on target audiences' knowledge, attitudes, cheap seroquel canada and beliefs as they relate to antidepressant drugs, antidepressant drugs vaccination, boosting, and uptake of vaccination among eligible children, as well as adherence to preventative behaviors.

It will also keep key stakeholders informed of the Campaign's progress. Ultimately, the data will inform a thorough evaluation of the efficacy of the campaign and its impact on treatment and booster uptake. antidepressant drugs Attitudes and Beliefs Survey (CABS) The CABS is a longitudinal survey that fields tri-annually to 4,000 cheap seroquel canada U.S. Adults through the duration of 0990-0475 via NORC at the University of Chicago's AmeriSpeak Panel.

The survey is fielded online, and each fielding period lasts between 3 and 6 weeks. Those that respond to each wave of the survey cheap seroquel canada are recontacted in each subsequent wave, facilitating a comparison of antidepressant drugs behavior change over time for a representative sample and evaluation of U.S. Adults. Panel members selected to participate in the study received one pre-invitation postcard in the mail, one email invitation, and three email reminders to complete the survey in each wave.

There are two CABS supplements to cheap seroquel canada increase robustness of the evaluation, one to obtain enough parent respondents of eligible-to-vaccinate children and another to obtain respondents' media consumption habits. Monthly Outcome Survey (MOS) The MOS is a cross-sectional survey fielded monthly to 5,000 U.S. Adults over two years (24 waves) via the Ipsos KnowledgePanel 5K Omnibus Survey. The is fielded online, and each fielding period lasts between 7 and 10 days.

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But experts say they'd be better off going to their doctor and asking http://unitedpunjabisofamerica.org/can-you-buy-ventolin-over-the-counter-in-australia for clinically proven treatments rather than relying seroquel and ativan on an herbal remedy. There's scant clinical evidence that supplements like black cohosh, soy isoflavone, Swedish pollen, magnolia bark and melatonin provide effective relief for menopause symptoms, said Dr. Jennifer Howell, an obstetrician and gynecologist at Duke Health in Durham, N.C. "The ingredients in most supplements have been seroquel and ativan studied and have not been shown to be better than placebo over time," Howell said. "Most of them are reasonably safe.

You are fine to try them. But it is hard for me seroquel and ativan to endorse them." The supplement most widely touted as a menopause remedy — black cohosh — has been shown in two high-quality clinical trials to be no better than placebo, according to the U.S. National Institutes of Health's (NIH) Office of Dietary Supplements. Worse, in rare instances, black cohosh can cause liver damage. "Some experts actively discourage it because there's no evidence that black cohosh works, and some patients will experience some liver inflammation from it," seroquel and ativan Howell said.

Soy isoflavones — essentially, plant-based estrogens — have had some mixed results in treating menopause symptoms, the NIH says. Howell cautions women who have an increased risk of cancer to talk with their doctor before trying soy isoflavones, since estrogen can fuel some tumors. An extract derived seroquel and ativan from the roots of rhapontic, or false rhubarb, is used in some proprietary herbal supplements for menopause. One small-scale clinical trial in Germany has shown some benefit for the extract compared to placebo, but no follow-up research has taken place. One of the problems with these and other supplements is that they are not regulated by the U.S.

Food and Drug Administration, Howell said seroquel and ativan. "They can make claims and they don't have to be supported by vigorous scientific data as a pharmaceutical would," she said. Experts also warn that there's little to no evidence for another "herbal" product increasingly used by menopausal women — marijuana. Cannabis and wine are two remedies seroquel and ativan that women have turned to for decades when dealing with menopause, said Dr. Suzanne Fenske, an assistant clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai, in New York City.

Marijuana legalization has led more women to try pot for menopause relief. A study presented at the 2020 meeting of the seroquel and ativan North American Menopause Society found that more than one-quarter of female U.S. Veterans had used marijuana to treat their menopause, and another 10% planned to give it a try. "People are still turning to wine and cannabis, and now we're finally kind of evaluating it," Fenske said. But most seroquel and ativan research into marijuana and women's health has so far focused on pot use during pregnancy and breastfeeding, according to a 2021 evidence review in the journal Cannabis and Cannabinoid Research.

QUESTION If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer "Although some users may find cannabis to be beneficial for ameliorating signs and symptoms commonly associated with menopause... (e.g., insomnia, irritability, joint pain, depression), there are few data on seroquel and ativan the efficacy and safety of cannabis use in this context," the review concluded. Howell said her concerns about the use of marijuana to relieve menopause symptoms spring in part from her knowledge of the history of treatment during the change of life. For decades, women were diagnosed as neurotic and loaded up on tranquilizers if they were struggling with the transition.

"We've already been there and done that with addictive medicines given to women for menopause," Howell seroquel and ativan said. "I don't personally have a lot of interest in it. Women were prescribed barbiturates and highly addictive sedatives and sleeping pills for menopause in the past, which is really difficult and dangerous to stop." Women who try supplements probably would be better off talking to their doctor about hormone replacement therapy, Fenske and Howell said. Hormone replacement seroquel and ativan therapy delivers menopause symptom relief that's more significant than what is seen with supplements, Fenske said. On top of that, "if hormone replacement therapy is initiated within 10 years of menopause, there are actually some benefits" to overall health, Fenske said.

She noted that women who receive hormone therapy have a decreased risk of heart disease, colon cancer and osteoporosis. Hormone therapy seroquel and ativan was widely used starting in the 1960s, and even touted as "like being feminine forever," until the 2002 Women's Health Initiative study raised concerns that the treatment could increase risk of breast cancer, Fenske said. Newer studies and re-analysis of older studies also have shown that healthy women who take hormone replacement therapy for a short time around their transition actually have a lower risk of premature death from all causes, Howell said. The therapy usually is limited to three to five years. "I think it should be first-line for patients who are symptomatic around the time of menopause," seroquel and ativan Howell said.

"It shouldn't be, 'Try everything else and then we'll let you use this.'" A host of other medications have been shown to relieve specific symptoms like hot flashes or sleeplessness, including antidepressants and seizure medications, Howell said. Another way women can help ease their symptoms is by changing up their eating habits, Fenske said. "We know seroquel and ativan that nutrition is actually very important," she said. "You can have exacerbation of hot flashes and night sweats by what we put in our body." For example, a lot of carbohydrates in your diet can worsen hot flashes, as can drinking alcohol too close to bedtime, Fenske said. More information The Office on Women's Health has more about menopause symptoms and relief.

SOURCES. Jennifer Howell, MD, obstetrician and gynecologist, Duke Health, Durham, N.C.. Suzanne Fenske, MD, assistant clinical professor, obstetrics, gynecology and reproductive science, Icahn School of Medicine at Mount Sinai, New York City Copyright © 2021 HealthDay. All rights reserved. From Women's Health Resources Featured Centers Health Solutions From Our SponsorsLatest antidepressants News FRIDAY, Feb.

18, 2022 (HealthDay News) Journalistic fact checks do more to combat the spread of antidepressant drugs misinformation than false tags used by social media companies, a new study finds. Journalistic fact checks not only flag a post as false, but also provide information refuting the fake claim with links to more information. "We find that more information may be an antidote to misinformation," political scientists Sarah Kreps of Cornell University School of Law, and Douglas Kriner of the university's Department of Government, said in a Cornell news release. Kreps and Kriner are co-authors of the study, which was published Feb. 15 in the journal Public Opinion Quarterly.

Tags on social media that declare content false often partially obscure a post, but don't allow users to easily access the details of that fact check. In this study, Kreps and Kriner compared effectiveness of the two methods among more than 2,000 Americans who took part in two online surveys. Participants were shown false claims, including one by former President Donald Trump that the United States had tested more people for antidepressant drugs than all other countries combined. Tagging a claim as false had no effect on participants' perception of its accuracy, and, the study found, actually increased the likelihood they would share it on social media. In contrast, a journalistic fact check made people much less likely to believe a false claim, according to the study.

The researchers noted that the antidepressant drugs seroquel has given rise to a flood of misinformation that prompts people to take measures that are ineffective at best and harmful at worst. Sharing habits and actions on social media offer a useful window into how people process information and misinformation, according to the study authors. Previous research has shown that sharing is an important indicator because it can extend the reach of news, and a self-reported willingness to share offers genuine insight into what people will do on social media, they explained. Journalistic fact checks are commonly used to check statements made by political candidates. The researchers said this study is among the first to assess fact checks in the context of antidepressant drugs information.

More information The College of Staten Island/City University of New York has a list of antidepressant drugs factchecking websites. SOURCE. Cornell University, news release, Feb. 16, 2022 Copyright © 2021 HealthDay. All rights reserved.Latest Skin News FRIDAY, Feb.

18, 2022 Six Brut and Sure aerosol antiperspirant and deodorant sprays sold in the United States and Canada have been recalled by their maker due to the presence of the chemical benzene. "Benzene is classified as a human carcinogen. Exposure to benzene can occur by inhalation, orally, and through the skin and it can result in cancers including leukemia and blood cancer of the bone marrow and blood disorders which can be life-threatening," stated a news release from TCP HOT Acquisition LLC dba HRB Brands. "While benzene is not an ingredient in any of the recalled products, our review showed that unexpected levels of benzene came from the propellant that sprays the product out of the can," the company said. But it added that there have been no reports of adverse events related to the recall, which is being conducted out of an "abundance of caution." Similar recalls have been issued for other consumer products that surprisingly contained benzene in the past six months.

Pantene/Herbal Essence dry spray shampoos. Old Spice spray deodorants. And Neutrogena/Aveeno spray sunscreens. Five of TCP's recalled products are. Brut Classic Antiperspirant Aerosol (4 oz) (UPC 00827755070085).

Brut Classic Antiperspirant Aerosol (6 oz) (UPC 000827755070108). Brut Classic Deodorant Aerosol (10.0 oz) (UPC 00827755070047). Sure Regular Antiperspirant Aerosol (6.0 oz) (UPC 00883484002025). Sure Unscented Antiperspirant Aerosol (6.0 oz) (UPC 00883484002278). A sixth recalled product was sold only in Canada.

Brut Classic Deodorant Aerosol (154g) (UPC 00827755070177). Consumers should stop using the recalled products immediately and dispose of them appropriately, said the company, which also advised consumers to contact a health care provider if they experience any problems that may be associated with use of the recalled products. For more information or to request a refund, consumers can contact the company at 1-866-615-0976 or go to its website. More information Visit the U.S. Environmental Protection Agency for more on benzene.

SOURCE. TCP HOT Acquisition LLC dba HRB Brands, news release, Feb. 17, 2022 Copyright © 2021 HealthDay. All rights reserved. SLIDESHOW Skin &.

Beauty. Anti-Aging Tips &. Secrets to Look Younger See SlideshowLatest Prevention &. Wellness News FRIDAY, Feb. 18, 2022 (HealthDay News) Fracking has already raised the ire of environmentalists for its effects on the planet, but new research sends up another red flag.

The wastewater produced by the complicated oil and gas drilling process is loaded with toxic and cancer-causing contaminants that threaten both people and wildlife. In fracking, water that contains a number of additives is used in the drilling process. This injected water mixes with groundwater and resurfaces as a waste byproduct containing both the additives and contaminants from the drilling site. In this study, researchers analyzed untreated fracking wastewater samples from the Permian Basin and Eagle Ford formation, both in Texas, and found 266 different dissolved organic compounds. They included.

A pesticide called atrazine. 1,4-dioxane, an organic compound that is irritating to the eyes and respiratory tract. Pyridine, a chemical that may damage the liver. And polycyclic aromatic hydrocarbons (PAHs), which have been linked to skin, lung, bladder, liver and stomach cancers. In the water, 29 elements were also detected, including rare earth elements, selenium and hazardous metals such as chromium, cadmium, lead and uranium, according to the study.

The findings were released as regulators work on proposed guidelines for the safe treatment and disposal of fracking wastewater. "The discovery of these chemicals in [fracking wastewater] suggests that greater monitoring and remediation efforts are needed, since many of them are listed to be dangerous for human health by the World Health Organization," said study author Emanuela Gionfriddo, an assistant professor of analytical chemistry in the School of Green Chemistry and Engineering at the University of Toledo in Ohio. "Our comprehensive characterization sheds insight into the processes taking place during hydraulic fracturing and the nature of the geologic formation of each well site," Gionfriddo added in a university news release. The researchers analyzed the fracking wastewater using new technology they developed, and said the technology is essential for proper reuse or disposal of fracking wastewater by oil and gas producers. The study was published recently in the journal Environmental Science and Technology.

More information There's more on fracking and health at the U.S. National Institute of Environmental Health Sciences. SOURCE. University of Toledo, news release, Feb. 17, 2022 Copyright © 2021 HealthDay.

All rights reserved. SLIDESHOW The 14 Most Common Causes of Fatigue See Slideshow.

But experts say they'd be better off going to their doctor cheap seroquel canada and asking for clinically proven treatments rather than relying on an herbal remedy. There's scant clinical evidence that supplements like black cohosh, soy isoflavone, Swedish pollen, magnolia bark and melatonin provide effective relief for menopause symptoms, said Dr. Jennifer Howell, an obstetrician and gynecologist at Duke Health in Durham, N.C. "The ingredients in most supplements have been studied and have not been shown cheap seroquel canada to be better than placebo over time," Howell said.

"Most of them are reasonably safe. You are fine to try them. But it is hard for me to endorse them." The supplement most widely touted as a menopause remedy — black cohosh — has been shown in two cheap seroquel canada high-quality clinical trials to be no better than placebo, according to the U.S. National Institutes of Health's (NIH) Office of Dietary Supplements.

Worse, in rare instances, black cohosh can cause liver damage. "Some experts actively discourage it because cheap seroquel canada there's no evidence that black cohosh works, and some patients will experience some liver inflammation from it," Howell said. Soy isoflavones — essentially, plant-based estrogens — have had some mixed results in treating menopause symptoms, the NIH says. Howell cautions women who have an increased risk of cancer to talk with their doctor before trying soy isoflavones, since estrogen can fuel some tumors.

An extract derived from the cheap seroquel canada roots of rhapontic, or false rhubarb, is used in some proprietary herbal supplements for menopause. One small-scale clinical trial in Germany has shown some benefit for the extract compared to placebo, but no follow-up research has taken place. One of the problems with these and other supplements is that they are not regulated by the U.S. Food and Drug Administration, cheap seroquel canada Howell said.

"They can make claims and they don't have to be supported by vigorous scientific data as a pharmaceutical would," she said. Experts also warn that there's little to no evidence for another "herbal" product increasingly used by menopausal women — marijuana. Cannabis and wine are two remedies that women have turned to for decades when dealing cheap seroquel canada with menopause, said Dr. Suzanne Fenske, an assistant clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai, in New York City.

Marijuana legalization has led more women to try pot for menopause relief. A study presented at the 2020 meeting of the North American Menopause Society found that more cheap seroquel canada than one-quarter of female U.S. Veterans had used marijuana to treat their menopause, and another 10% planned to give it a try. "People are still turning to wine and cannabis, and now we're finally kind of evaluating it," Fenske said.

But most research into cheap seroquel canada marijuana and women's health has so far focused on pot use during pregnancy and breastfeeding, according to a 2021 evidence review in the journal Cannabis and Cannabinoid Research. QUESTION If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer "Although some users may find cannabis to be beneficial for ameliorating signs and symptoms commonly associated with menopause... (e.g., insomnia, irritability, joint pain, depression), there are few data on the efficacy and safety cheap seroquel canada of cannabis use in this context," the review concluded.

Howell said her concerns about the use of marijuana to relieve menopause symptoms spring in part from her knowledge of the history of treatment during the change of life. For decades, women were diagnosed as neurotic and loaded up on tranquilizers if they were struggling with the transition. "We've already been there and done that with addictive medicines given to women for menopause," cheap seroquel canada Howell said. "I don't personally have a lot of interest in it.

Women were prescribed barbiturates and highly addictive sedatives and sleeping pills for menopause in the past, which is really difficult and dangerous to stop." Women who try supplements probably would be better off talking to their doctor about hormone replacement therapy, Fenske and Howell said. Hormone replacement therapy delivers menopause symptom relief cheap seroquel canada that's more significant than what is seen with supplements, Fenske said. On top of that, "if hormone replacement therapy is initiated within 10 years of menopause, there are actually some benefits" to overall health, Fenske said. She noted that women who receive hormone therapy have a decreased risk of heart disease, colon cancer and osteoporosis.

Hormone therapy was widely used starting in the 1960s, and even touted as "like being feminine forever," until the cheap seroquel canada 2002 Women's Health Initiative study raised concerns that the treatment could increase risk of breast cancer, Fenske said. Newer studies and re-analysis of older studies also have shown that healthy women who take hormone replacement therapy for a short time around their transition actually have a lower risk of premature death from all causes, Howell said. The therapy usually is limited to three to five years. "I think it should be first-line for patients who cheap seroquel canada are symptomatic around the time of menopause," Howell said.

"It shouldn't be, 'Try everything else and then we'll let you use this.'" A host of other medications have been shown to relieve specific symptoms like hot flashes or sleeplessness, including antidepressants and seizure medications, Howell said. Another way women can help ease their symptoms is by changing up their eating habits, Fenske said. "We know that nutrition is cheap seroquel canada actually very important," she said. "You can have exacerbation of hot flashes and night sweats by what we put in our body." For example, a lot of carbohydrates in your diet can worsen hot flashes, as can drinking alcohol too close to bedtime, Fenske said.

More information The Office on Women's Health has more about menopause symptoms and relief. SOURCES. Jennifer Howell, MD, obstetrician and gynecologist, Duke Health, Durham, N.C.. Suzanne Fenske, MD, assistant clinical professor, obstetrics, gynecology and reproductive science, Icahn School of Medicine at Mount Sinai, New York City Copyright © 2021 HealthDay.

All rights reserved. From Women's Health Resources Featured Centers Health Solutions From Our SponsorsLatest antidepressants News FRIDAY, Feb. 18, 2022 (HealthDay News) Journalistic fact checks do more to combat the spread of antidepressant drugs misinformation than false tags used by social media companies, a new study finds. Journalistic fact checks not only flag a post as false, but also provide information refuting the fake claim with links to more information.

"We find that more information may be an antidote to misinformation," political scientists Sarah Kreps of Cornell University School of Law, and Douglas Kriner of the university's Department of Government, said in a Cornell news release. Kreps and Kriner are co-authors of the study, which was published Feb. 15 in the journal Public Opinion Quarterly. Tags on social media that declare content false often partially obscure a post, but don't allow users to easily access the details of that fact check.

In this study, Kreps and Kriner compared effectiveness of the two methods among more than 2,000 Americans who took part in two online surveys. Participants were shown false claims, including one by former President Donald Trump that the United States had tested more people for antidepressant drugs than all other countries combined. Tagging a claim as false had no effect on participants' perception of its accuracy, and, the study found, actually increased the likelihood they would share it on social media. In contrast, a journalistic fact check made people much less likely to believe a false claim, according to the study.

The researchers noted that the antidepressant drugs seroquel has given rise to a flood of misinformation that prompts people to take measures that are ineffective at best and harmful at worst. Sharing habits and actions on social media offer a useful window into how people process information and misinformation, according to the study authors. Previous research has shown that sharing is an important indicator because it can extend the reach of news, and a self-reported willingness to share offers genuine insight into what people will do on social media, they explained. Journalistic fact checks are commonly used to check statements made by political candidates.

The researchers said this study is among the first to assess fact checks in the context of antidepressant drugs information. More information The College of Staten Island/City University of New York has a list of antidepressant drugs factchecking websites. SOURCE. Cornell University, news release, Feb.

16, 2022 Copyright © 2021 HealthDay. All rights reserved.Latest Skin News FRIDAY, Feb. 18, 2022 Six Brut and Sure aerosol antiperspirant and deodorant sprays sold in the United States and Canada have been recalled by their maker due to the presence of the chemical benzene. "Benzene is classified as a human carcinogen.

Exposure to benzene can occur by inhalation, orally, and through the skin and it can result in cancers including leukemia and blood cancer of the bone marrow and blood disorders which can be life-threatening," stated a news release from TCP HOT Acquisition LLC dba HRB Brands. "While benzene is not an ingredient in any of the recalled products, our review showed that unexpected levels of benzene came from the propellant that sprays the product out of the can," the company said. But it added that there have been no reports of adverse events related to the recall, which is being conducted out of an "abundance of caution." Similar recalls have been issued for other consumer products that surprisingly contained benzene in the past six months. Pantene/Herbal Essence dry spray shampoos.

Old Spice spray deodorants. And Neutrogena/Aveeno spray sunscreens. Five of TCP's recalled products are. Brut Classic Antiperspirant Aerosol (4 oz) (UPC 00827755070085).

Brut Classic Antiperspirant Aerosol (6 oz) (UPC 000827755070108). Brut Classic Deodorant Aerosol (10.0 oz) (UPC 00827755070047). Sure Regular Antiperspirant Aerosol (6.0 oz) (UPC 00883484002025). Sure Unscented Antiperspirant Aerosol (6.0 oz) (UPC 00883484002278).

A sixth recalled product was sold only in Canada. Brut Classic Deodorant Aerosol (154g) (UPC 00827755070177). Consumers should stop using the recalled products immediately and dispose of them appropriately, said the company, which also advised consumers to contact a health care provider if they experience any problems that may be associated with use of the recalled products. For more information or to request a refund, consumers can contact the company at 1-866-615-0976 or go to its website.

More information Visit the U.S. Environmental Protection Agency for more on benzene. SOURCE. TCP HOT Acquisition LLC dba HRB Brands, news release, Feb.

17, 2022 Copyright © 2021 HealthDay. All rights reserved. SLIDESHOW Skin &. Beauty.

Anti-Aging Tips &. Secrets to Look Younger See SlideshowLatest Prevention &. Wellness News FRIDAY, Feb. 18, 2022 (HealthDay News) Fracking has already raised the ire of environmentalists for its effects on the planet, but new research sends up another red flag.

The wastewater produced by the complicated oil and gas drilling process is loaded with toxic and cancer-causing contaminants that threaten both people and wildlife. In fracking, water that contains a number of additives is used in the drilling process. This injected water mixes with groundwater and resurfaces as a waste byproduct containing both the additives and contaminants from the drilling site. In this study, researchers analyzed untreated fracking wastewater samples from the Permian Basin and Eagle Ford formation, both in Texas, and found 266 different dissolved organic compounds.

They included. A pesticide called atrazine. 1,4-dioxane, an organic compound that is irritating to the eyes and respiratory tract. Pyridine, a chemical that may damage the liver.

And polycyclic aromatic hydrocarbons (PAHs), which have been linked to skin, lung, bladder, liver and stomach cancers. In the water, 29 elements were also detected, including rare earth elements, selenium and hazardous metals such as chromium, cadmium, lead and uranium, according to the study. The findings were released as regulators work on proposed guidelines for the safe treatment and disposal of fracking wastewater. "The discovery of these chemicals in [fracking wastewater] suggests that greater monitoring and remediation efforts are needed, since many of them are listed to be dangerous for human health by the World Health Organization," said study author Emanuela Gionfriddo, an assistant professor of analytical chemistry in the School of Green Chemistry and Engineering at the University of Toledo in Ohio.

"Our comprehensive characterization sheds insight into the processes taking place during hydraulic fracturing and the nature of the geologic formation of each well site," Gionfriddo added in a university news release. The researchers analyzed the fracking wastewater using new technology they developed, and said the technology is essential for proper reuse or disposal of fracking wastewater by oil and gas producers. The study was published recently in the journal Environmental Science and Technology. More information There's more on fracking and health at the U.S.

National Institute of Environmental Health Sciences. SOURCE. University of Toledo, news release, Feb. 17, 2022 Copyright © 2021 HealthDay.

All rights reserved. SLIDESHOW The 14 Most Common Causes of Fatigue See Slideshow.

Does seroquel lower seizure threshold

(SACRAMENTO) Nathan Kuppermann, chair of the Department of Emergency Medicine, has received the Maureen Andrew Mentor does seroquel lower seizure threshold Award from the Society for Pediatric Research. This national award honors one academic pediatrician annually who has an outstanding record of mentorship and leadership.Nathan KuppermannEstablished in 2003, the award honors the contributions of Maureen Andrew, a past Society for Pediatric Research president whose work advanced the field of child health research.“I am honored to receive this award for mentoring many physicians who have gone on to be leaders in pediatric emergency care,” said Kuppermann. €œThroughout my own career, I have been incredibly does seroquel lower seizure threshold fortunate to have received outstanding mentorship. I have strived to ‘pay it forward’ and encourage, teach and guide those whom I have served as mentor.”Throughout his 30 years in pediatric emergency medicine, Kuppermann has provided mentorship to students, residents, fellows and faculty at UC Davis Health. Nationally, he has helped create numerous mentoring programs including with the Pediatric Emergency Medicine Collaborative Research does seroquel lower seizure threshold Committee (PEM CRC) of the American Academy of Pediatrics, the Pediatric Emergency Care Applied Research Network (PECARN) and the Clinical Research on Emergency Services and Treatments Network (CREST) of Kaiser Permanente.

I would like to thank all the students, trainees and faculty members with whom I have worked. This award reflects their success as does seroquel lower seizure threshold much as my own, and in the process, I have learned as much as I have taught.” —Nathan KuppermannInternationally Kuppermann helped develop a pediatric emergency care research network in Argentina, which has expanded throughout South America. He was also a founding member and executive committee member of the Pediatric Emergency Research Network (PERN), which is a constellation of eight international pediatric emergency care research networks.“As a physician, my highest priority is always caring for my patients. However, being at an academic medical center provides me the great opportunity, responsibility and honor to advise and guide the next generation of emergency physicians,” said Kuppermann. €œI would like to thank all the students, trainees and faculty members with whom I does seroquel lower seizure threshold have worked.

This award reflects their success as much as my own, and in the process, I have learned as much as I have taught.”(SACRAMENTO) A natural product from the dried root of a pea-family plant, combined with an enzyme inhibitor discovered in the laboratory of Professor Bruce Hammock, may provide hope in alleviating neuroinflammation in Parkinson’s disease. A team of researchers does seroquel lower seizure threshold from UC Davis and Dalian Medical University, China, announced the findings Feb. 21 in the Proceedings of the National of Academy of Sciences. The team found that a soluble epoxide hydrolase (sEH) inhibitor combined does seroquel lower seizure threshold with kurarinone, a compound from the dried root of Sophora flavescens, reduced neuroinflammation in an animal model with Parkinson’s disease. The dried root, also known as kushen, has been used for hundreds of years in traditional Chinese medicines.Sophora flavescens (Wikimedia commons)“Traditional Chinese medicines play an immeasurable role in the treatment of all kinds of diseases,” said lead researcher Cheng-Peng Sun, a Dalian Medical University professor who is partnering with the Hammock lab.

For the past 35 years, Hammock, a distinguished professor in the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, has researched enzyme inhibitors that dramatically reduce inflammation, inflammatory pain and neuropathic pain.“We investigated the neuroprotective effects of does seroquel lower seizure threshold S. Flavescens in Parkinson’s disease based on the neuroinflammation,” Sun said. €œOur extensive studies indicated that kurarinone possesses several pharmacological effects, including anti-inflammatory and antioxidative activities.”The researchers hope the work may lead to an effective therapy for Parkinson’s disease, an incurable, progressive neurogenerative disorder that affects more than 10 million people worldwide, including about million in the United States, according to the Mayo Clinic. The disease affects about 50 does seroquel lower seizure threshold percent more men than women. €œKurarinone targets the soluble epoxide hydrolase (sEH), which is a key regulatory enzyme involved in the metabolism of fatty acids, and inhibitors of the sEH enzyme resolve neuroinflammation,” said Hammock, a corresponding author of the paper.

€œThe enzyme does seroquel lower seizure threshold regulates a newly studied class of natural chemical mediators, which in turn regulate inflammation, blood pressure and pain. We have known for a number of years that the soluble epoxide hydrolase inhibitors, now in human safety trials, are active in reducing the development of Parkinson’s disease in several rodent models.”—Bruce HammockNovel mechanism of action“We have known for a number of years that the soluble epoxide hydrolase inhibitors, now in human safety trials, are active in reducing the development of Parkinson’s disease in several rodent models,” Hammock said. €œThe evidence for this is quite strong, particularly based on the work of our long-term collaborator Kenji Hashimoto at Chiba University in Japan.” Because of regulatory differences, a natural product offers a potentially faster route to does seroquel lower seizure threshold relief for patients than a classical pharmaceutical, Hammock said. Kurarinone has a novel mechanism compared to other sEH inhibitors, binding the enzyme in an adjacent but non-identical site. This provides a new model for the design of still more active compounds to block neuroinflammation associated with diseases where sEH inhibitors have shown efficacy in rodent models, including Alzheimer’s disease, Autism Spectrum Disorder and other disorders, Hammock said.

The research used a model of Parkinson’s Disease in mice treated with does seroquel lower seizure threshold MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Parkinson-like behaviors were significantly alleviated in mice treated with kurarinone. When tested in gene-modified mice with their sEH gene knocked out, kurarinone did not provide additional does seroquel lower seizure threshold protection. Sophora (the Arabic name for a pea-flowered tree) is a genus of about 45 species of evergreen trees and shrubs in the pea family, Fabaceae. The species are native to does seroquel lower seizure threshold southern Asia, Australasia, various Pacific islands, western South America, the western United States, Florida and Puerto Rico.

About fifteen of these species have a long history of use in traditional Chinese medicines. Additional authors on the paper are Christophe Morriseau at UC Davis and Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang and Xiao-Chi Ma, Dalian Medical University..

(SACRAMENTO) Nathan Kuppermann, More Bonuses chair of the Department of Emergency Medicine, has received cheap seroquel canada the Maureen Andrew Mentor Award from the Society for Pediatric Research. This national award honors one academic pediatrician annually who has an outstanding record of mentorship and leadership.Nathan KuppermannEstablished in 2003, the award honors the contributions of Maureen Andrew, a past Society for Pediatric Research president whose work advanced the field of child health research.“I am honored to receive this award for mentoring many physicians who have gone on to be leaders in pediatric emergency care,” said Kuppermann. €œThroughout my own career, I have been cheap seroquel canada incredibly fortunate to have received outstanding mentorship. I have strived to ‘pay it forward’ and encourage, teach and guide those whom I have served as mentor.”Throughout his 30 years in pediatric emergency medicine, Kuppermann has provided mentorship to students, residents, fellows and faculty at UC Davis Health. Nationally, he has helped create cheap seroquel canada numerous mentoring programs including with the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC) of the American Academy of Pediatrics, the Pediatric Emergency Care Applied Research Network (PECARN) and the Clinical Research on Emergency Services and Treatments Network (CREST) of Kaiser Permanente.

I would like to thank all the students, trainees and faculty members with whom I have worked. This award reflects their success as cheap seroquel canada much as my own, and in the process, I have learned as much as I have taught.” —Nathan KuppermannInternationally Kuppermann helped develop a pediatric emergency care research network in Argentina, which has expanded throughout South America. He was also a founding member and executive committee member of the Pediatric Emergency Research Network (PERN), which is a constellation of eight international pediatric emergency care research networks.“As a physician, my highest priority is always caring for my patients. However, being at an academic medical center provides me the great opportunity, responsibility and honor to advise and guide the next generation of emergency physicians,” said Kuppermann. €œI would like to thank all the cheap seroquel canada students, trainees and faculty members with whom I have worked.

This award reflects their success as much as my own, and in the process, I have learned as much as I have taught.”(SACRAMENTO) A natural product from the dried root of a pea-family plant, combined with an enzyme inhibitor discovered in the laboratory of Professor Bruce Hammock, may provide hope in alleviating neuroinflammation in Parkinson’s disease. A team cheap seroquel canada of researchers from UC Davis and Dalian Medical University, China, announced the findings Feb. 21 in the Proceedings of the National of Academy of Sciences. The team found that a soluble epoxide hydrolase (sEH) inhibitor combined with kurarinone, a compound cheap seroquel canada from the dried root of Sophora flavescens, reduced neuroinflammation in an animal model with Parkinson’s disease. The dried root, also known as kushen, has been used for hundreds of years in traditional Chinese medicines.Sophora flavescens (Wikimedia commons)“Traditional Chinese medicines play an immeasurable role in the treatment of all kinds of diseases,” said lead researcher Cheng-Peng Sun, a Dalian Medical University professor who is partnering with the Hammock lab.

For the past 35 years, Hammock, a distinguished professor in the cheap seroquel canada Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, has researched enzyme inhibitors that dramatically reduce inflammation, inflammatory pain and neuropathic pain.“We investigated the neuroprotective effects of S. Flavescens in look at more info Parkinson’s disease based on the neuroinflammation,” Sun said. €œOur extensive studies indicated that kurarinone possesses several pharmacological effects, including anti-inflammatory and antioxidative activities.”The researchers hope the work may lead to an effective therapy for Parkinson’s disease, an incurable, progressive neurogenerative disorder that affects more than 10 million people worldwide, including about million in the United States, according to the Mayo Clinic. The disease affects about 50 percent more men cheap seroquel canada than women. €œKurarinone targets the soluble epoxide hydrolase (sEH), which is a key regulatory enzyme involved in the metabolism of fatty acids, and inhibitors of the sEH enzyme resolve neuroinflammation,” said Hammock, a corresponding author of the paper.

€œThe enzyme regulates a newly studied class of natural chemical mediators, cheap seroquel canada which in turn regulate inflammation, blood pressure and pain. We have known for a number of years that the soluble epoxide hydrolase inhibitors, now in human safety trials, are active in reducing the development of Parkinson’s disease in several rodent models.”—Bruce HammockNovel mechanism of action“We have known for a number of years that the soluble epoxide hydrolase inhibitors, now in human safety trials, are active in reducing the development of Parkinson’s disease in several rodent models,” Hammock said. €œThe evidence for this is quite strong, particularly based on the work of our long-term collaborator Kenji Hashimoto at Chiba University in Japan.” Because of regulatory differences, a natural product offers a potentially faster route to cheap seroquel canada relief for patients than a classical pharmaceutical, Hammock said. Kurarinone has a novel mechanism compared to other sEH inhibitors, binding the enzyme in an adjacent but non-identical site. This provides a new model for the design of still more active compounds to block neuroinflammation associated with diseases where sEH inhibitors have shown efficacy in rodent models, including Alzheimer’s disease, Autism Spectrum Disorder and other disorders, Hammock said.

The research used a model of cheap seroquel canada Parkinson’s Disease in mice treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Parkinson-like behaviors were significantly alleviated in mice treated with kurarinone. When tested in gene-modified cheap seroquel canada mice with their sEH gene knocked out, kurarinone did not provide additional protection. Sophora (the Arabic name for a pea-flowered tree) is a genus of about 45 species of evergreen trees and shrubs in the pea family, Fabaceae. The species are native to southern Asia, Australasia, various Pacific islands, western South America, the cheap seroquel canada western United States, Florida and Puerto Rico.

About fifteen of these species have a long history of use in traditional Chinese medicines. Additional authors on the paper are Christophe Morriseau at UC Davis and Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang and Xiao-Chi Ma, Dalian Medical University..